Page 168 - Ghidul Serviciilor Medicale Synevo, Ediția 1

Creşterea APO B Scăderea APO B
• hiperlipoproteinemie,• deficit de • afecŃiuni hepatice,• hipo şi abetalipoproteinemie,
apoproteină E, • hiper-apo-beta- • malabsorbŃie/malnutriŃie,• sindrom Reye,
lipoproteinemie familială, • hipotiroidism,• deficit de APO C-II,
3;4
• sindrom nefrotic,• sarcină,• obstrucŃie • hiperlipidemie de tip I,• alfa-beta-lipoproteinemie, • eforturi,• infecŃii .
biliară,• hemodializă, • fumat, • diabet,
• hipotiroidism,• disglobulinemie,
3;4
• porfirie,• Sindrom Cushing .

Limite şi interferenŃe APO A-I
• Medicamente
Creşteri : carbamazepină, furosemid, contraceptive orale, fenobarbital, fenitoin, prednisolon, derivaŃi ai
2
acidului fibric (ex. clofibrat, gemfibrozil) .
2
Scăderi : lovastatin .
Limite şi interferenŃe APO B
• Medicamente
Creşteri: amiodaronă, atenolol, ciclosporină, estrogeni, furosemid, metoprolol, fenobarbital, iod radioactiv, androgeni
(steroizi anabolizanŃi), chlortialidonă, gemfibrozil, isotretinoin, levonorgestrel, contraceptive orale, simvastatin,
stanozolol .
2
Scăderi: captopril, indometacin, interferon, ketoconazol, neomicină, niacin, nifedipin, prazosin, prednisolon, tacrolimus,
colestiramină, colestipol, estrogeni (post-menopauză), derivaŃi ai acidului fibric (ex: clofibrat, gemfibrozil), simvastatin,
lovastatin, pravastatin, ketoconazol, neomicina, niacin etc.
2

Bibliografie

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2. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In A Manual of Laboratory and
Diagnostic Tests. Lippincott Williams & Wilkins, USA, 7 ed. 2004, 1188-1238.
3. Frances Fischbach. Chemistry Studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 7 ed. 2004,
428-30.
4. Jacques Wallach.Boli metabolice şi ereditare. În Interpretarea testelor de diagnostic. Editura ŞtiinŃelor Medicale, România, 7 ed. 2001, 653-
752.
5. Laborator Synevo. ReferinŃele specifice tehnologiei de lucru utilizate 2006. Ref Type: Catalog
6. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Apolipoproteina A-1. www.labcorp.com 2006 Ref Type:
Internet Communication
7. Maciejko JJ, Holmes DR, Kottke BA, et al. (1983), Apolipoprotein A-1 as a Marker of Angiographically Assessed Coronary-Artery Disease.
In N Engl J Med 309(7):385-9:
8. Miller NE. Association of High Density Lipoprotein Subclasses and Apolipoproteins with Ischemic Heart Disease and Coronary
Atherosclerosis. In Am Heart J 113(2 ):587-97. 1987. Ref Type: Journal (Full)
9. Naito HK. The Clinical Significance of Apolipoprotein Measurements. In J Clin Immunoassay 9:11-20. 1986. Ref Type: Journal (Full).