Page 495 - Ghidul Serviciilor Medicale Synevo, Ediția 2, Volum 1

GHIDUL SERVICIILOR MEDICALE 8
AL LABORATOARELOR SYNEVO TESTE DE BIOCHIMIE

Limite şi interferenţe APO A-1
• Medicamente
Creşteri: carbamazepină, furosemid, contraceptive orale, fenobarbital, fenitoin, prednisolon, derivaţi ai
acidului fibric (ex. clofibrat, gemfibrozil) .
2
Scăderi : lovastatin .
2
Limite şi interferenţe APO B
• Medicamente
Creşteri: amiodaronă, atenolol, ciclosporină, estrogeni, furosemid, metoprolol, fenobarbital, iod
radioactiv, androgeni (steroizi anabolizanţi), chlortialidonă, gemfibrozil, isotretinoin, levonorgestrel,
contraceptive orale, simvastatin, stanozolol . 2
Scăderi: captopril, indometacin, interferon, ketoconazol, neomicină, niacin, nifedipin, prazosin,
prednisolon, tacrolimus, colestiramină, colestipol, estrogeni (post-menopauză), derivaţi ai acidului
fibric (ex: clofibrat, gemfibrozil), simvastatin, lovastatin, pravastatin, ketoconazol, neomicina, niacin 2
etc.
• Interferenţe analitice
În cazuri foarte rare prezenţa gamapatiei, în special IgM (macroglobulinemia Waldenström) poate
determina rezultate eronate .
5
Bibliografie

1. Alaupovic P. Apolipoproteins and Lipoproteins. In Atherosclerosis 13(2):141-6. 1971 Ref Type:
Journal (Full)
2. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory
Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 ed.
2009, 1227.
3. Frances Fischbach. Chemistry Studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott
Williams & Wilkins, USA, 8 ed. 2009, 455-456.
4. Jacques Wallach.Boli metabolice şi ereditare. În Interpretarea testelor de diagnostic. Editura
Ştiinţelor Medicale, România, 7 ed. 2001, 653-752.
5. Laborator Synevo. Referinţele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog
6. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Apolipoproteina
A-1. www.labcorp.com 2010 Ref Type: Internet Communication
7. Maciejko JJ, Holmes DR, Kottke BA, et al. (1983), Apolipoprotein A-1 as a Marker of
Angiographically Assessed Coronary-Artery Disease. In N Engl J Med 309(7):385-9:
8. Miller NE. Association of High Density Lipoprotein Subclasses and Apolipoproteins with Ischemic
Heart Disease and Coronary Atherosclerosis. In Am Heart J 113(2 ):587-97. 1987. Ref Type: Journal
(Full).
9. Naito HK. The Clinical Significance of Apolipoprotein Measurements. In J Clin Immunoassay 9:11-
20. 1986. Ref Type: Journal (Full).

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